Velocardiofacial syndrome - a syndrome with many faces

Melinda Lombard, JL Roos

Abstract


Velocardiofacial Syndrome (VCFS) can present with many different features. In this paper we review some of these features: working memory deficits, dysmorphic features, co-morbid obsessive compulsive disorder (OCD), early deviant behaviour, functional impairment, and early age of onset of schizophrenia. Some uncommon features found in the five patients studied are discussed. Genetic counselling in these patients and what the future holds in terms of treatment are mentioned. Patients with VCFS can have covert symptoms that can easily be overlooked. For this reason, guidelines to the detection of the abnormalities in these patients are given. The patients whose cases are reviewed are five patients who were diagnosed with VCFS during an ongoing genetic project on the study of schizophrenia in the Afrikaner founder population.

Keywords


VCFS, Pathological laughter, Working memory deficits, Late age of onset

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DOI: http://dx.doi.org/10.4102/sajpsychiatry.v17i3.305

Submitted: 04 May 2011
Published: 01 September 2011




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South African Journal of Psychiatry    |    ISSN: 1608-9685 (PRINT)    |    ISSN: 2078-6786 (ONLINE)